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Prior analyses have either used models that exclude the results of cardiovascular outcomes trials (with any reductions in cardiovascular and kidney outcomes being extrapolated only from changes in HbA 1c [13]), considered only specific high-risk populations [45, 46], or modelled the populations used in cardiovascular outcomes trials, which represent only 2060% of all people with type 2 diabetes [14]

Its multi-pathway design helps maintain steady energy levels and metabolic balance avoiding the energy crashes that can accompany aggressive caloric restriction

Psychological Contraindications to GLP-1 RA Therapy Conversely, specific psychological factors may contraindicate the use of GLP-1 RAs: Active Eating Disorders : The appetite-suppressing properties of GLP-1 RAs can be detrimental to individuals with active eating disorders

While the medication benefits many patients, recent research and regulatory reviews have identified a very rare but serious eye condition non-arteritic anterior ischemic optic neuropathy (NAION) that appears more often in some people taking semaglutide