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Third, we adopted a new-user design to minimize bias from prior drug exposure and to better emulate an RCT

Regional cerebral effects of ketone body infusion with 3-hydroxybutyrate in humans: reduced glucose uptake, unchanged oxygen consumption and increased blood flow by positron emission tomography

If a patient finds that the relief from each subsequent injection is diminishing or wearing off quickly, it usually suggests that the disease process is advancing

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And one of the hardest to diagnose without access to analytical chemistry tools like HPLC