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Growth hormone can theoretically stimulate tumor growth through its proliferative effects

Its anabolic and growth-promoting effects are largely indirect, primarily via stimulation of hepatic IGF-1 production, whilst its direct metabolic effects, particularly those related to lipid metabolism and adipose tissue regulation, are believed to be mediated by specific domains within the GH molecule itself

In vitro study using human vascular endothelial cells further confirmed the increased mRNA and protein expressions of VEGFR2 but not VEGF-A

Tanaffos 11(1):3843 Mosen DM, Schatz M, Magid DJ, Camargo CA (2008) Jr

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