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1000 g IM daily or every other day for 12 weeks, then 1000 g once weekly for 48 weeks

Prednisone increases hepatic glucose production and reduces insulin sensitivity

Losing weight very fast or eating far too little can trigger functional hypothalamic amenorrhea, where the body suppresses reproductive hormones to conserve energy

The PI3K/Akt pathway, which is positively induced by -catenin 118,119 , acts by phosphorylating GSK-3 to negatively regulate PPAR expression 120

NICE guideline NG28 recommends GLP-1 agonists for type 2 diabetes when metformin and other oral agents prove insufficient, particularly in people with a BMI 30 kg/m (or 27