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It is worth noting that the derivation of HBGVs applies extrapolation factors (also termed safety factors) to account for toxicodynamic and toxicokinetic differences between species and inter-individual variability in humans

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The 48 week trial data represents the full evolution of these benefits, with most meaningful changes appearing after 12-24 weeks of consistent treatment

Signal Transduct Target Ther 2023, 8: 267