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Plecanatide, an oral guanylate cyclase c agonist acting locally in the gastrointestinal tract, is safe and well-tolerated in single doses

Since chemotherapy-induced side effects are frequently also caused by mitochondrial ROS, such as cardiotoxicity or kidney injury after doxorubicin and cisplatin treatments, respectively, these potential redox therapies should be carefully directed to the target cells

However, tirzepatides effect on gastric emptying can alter the absorption of oral medications, so timing of any oral therapies should be discussed with a provider

The PCR was carried out on a CFX96TM Real-Time System and C1000 Touch Thermal Cycler (Bio-Rad)

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