doi: 10.1158/1078-0432.CCR-09-0265 338 Vanpouille-BoxCAlardAAryankalayilMJSarfrazYDiamondJMSchneiderRJet al
Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1
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Post-bariatric surgery patients Surgical alteration of the stomach or small intestine reduces the absorptive surface area for B12
Compared to GLP-1 agonists GLP-1 receptor agonists like semaglutide and tirzepatide have become extremely popular for weight loss