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Abstract Toxic metals such as arsenic, cadmium, lead, and mercury are ubiquitous, have no beneficial role in human homeostasis, and contribute to noncommunicable chronic diseases

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Mechanistically, SGLT2 inhibitors act predominantly through hemodynamic and cardiorenal pathways, whereas GLP-1 receptor agonists exert metabolic, anti-inflammatory, and anti-atherosclerotic effects, providing a rationale for potential complementarity