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Patients initiating GLP-1 RAs were less likely to start additional preventive medications, including valproate (risk ratio 0.52), calcitonin gene-related peptide monoclonal antibodies (risk ratio 0.58), tricyclic antidepressants (risk ratio 0.65), and gepants (risk ratio 0.77)

If you experience changes in libido or sexual function while taking tirzepatide, several situations warrant medical consultation

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These figures are drawn from controlled trials in which the medication was combined with lifestyle intervention

GLP-1RAs offer superior glycaemic control and weight loss compared with sitagliptin, likely because of the supraphysiological levels of the GLP-1RA provided in comparison with the physiological concentrations of GLP-1 and GIP achieved with sitagliptin