In vivo experiments indicated that AGNHP inhibits ROS, LPO, and Fe 2+ accumulations in MCAO and ICH rats ( in vitro experiments shown that AGNHP mitigated ferroptosis damage caused by erastin in PC12 cells, enhanced cell survival, decreased LPO and Fe 2+ concentrations, and boosted mRNA expressions of PPAR, AKT, and GPX4 ( Di-Huang-Yin-Zi (DHYZ) is a traditional herbal medicine employed for the prevention and treatment of neurological disorders since the Song Dynasty
The gradual dose escalation, usually at 4-week intervals, helps minimize gastrointestinal adverse effects that commonly occur with GLP-1 receptor agonist therapy
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