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Consider electroconvulsive therapy If an antidepressant is added, use mainly selective serotonin-reuptake inhibitors owing to the low switch rate

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A 2018 study in Endocrine found that combining a GHRH analog with a ghrelin mimetic produced IGF-1 increases 4060% higher than either compound alonebut the mechanism isn't simple addition

Final Thoughts For people with an MTHFR mutation, managing B12 levels is crucial to ensuring proper methylation, reducing homocysteine, and maintaining overall health

It is not approved for human use, clinical treatment, or athletic performance