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Importantly, not all variants confer increased risk: loss of function variants in HSD17B13, a lipid droplet-associated protein in hepatocytes, have been consistently associated with reduced hepatic inflammation and a lower risk of fibrosis and advanced liver disease [16]

[DOI] [PMC free article] [PubMed] 120.Rosenstock J, Buse JB, Azeem R, Prabhakar P, Kjems L, Huang H, et al