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The letter was personally addressed to the heads of the University of Bern, Lausanne University Hospital and University of Lausanne, accusing their employees of bad methodology

SPECTRUM proved a success with researchers, but 22nd Century aimed at going further with it and making it available for regular retail with a product called VLN which contains the same level of very low nicotine content as the lowest line of SPECTRUM cigarettes used in reduced nicotine cigarette research

The prevalence varied according to state, with the highest rates reported in West Virginia (28.7%), Arkansas (24.0%),Tennessee (19.7%), and Maine (19.5%)

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