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Although we were not able to find any studies concerning the effects of VIP on muc5B regulation and/or expression in asthma, since muc5B might be decreased in asthma [119], and VIP might also be decreased, then one speculation is that VIP directly stimulates production of muc5B
Moreover, this effect is combined to a downregulation of the expression of senescence-associated cytokines in the second model and an improvement of mice physical condition in the third model, respectively 37
Introduction Over the last several decades, much has been revealed about the nature and function of various immune mediators during the development of host innate immune responses to injury and infection, including cytokines, chemokines, and specific cell surface receptors which trigger a cascade of signaling pathways
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