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The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases

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Loss of proteostasis Proteostasis, or the regulation of protein quality and function, declines with age, resulting in the buildup of misfolded proteins and cellular malfunction

3) and was lower with tirzepatide compared with basal insulin (OR ranging from 0.17 with tirzepatide 5 mg to 0.25 with tirzepatide 15 mg) (ESM Fig