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The effects were assessed through self-reports, performance tests, sleep latency tests, and polysomnography

This sulfonamide ( 41 ) demonstrates a high metabolic stability and alters dendritic spine morphology and increases spine density in primary cultures of hippocampal neurons ( Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Figure 10)

Identified in the 1970s

In principle, ideal targets for anti-bacterial agents are H

And the weight loss curves at 24, 48, and 68 weeks tell fundamentally different stories about what each compound can achieve