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The permeability of the small hydrophilic marker dye fluorescein was at the level of non-treated control (4.75 10 6 cm/s) in all groups at basal conditions which was significantly increased by 40% after cytokine treatment (Fig

These results indicate that APR-246 induces p53-independent effects in these cells and that these off-target effects prevent us from detecting any mutant-specific effects even at low doses

The concept of a "BDNF peptide" refers to synthetic molecules designed to mimic the activity of full-length BDNF protein at the TrkB receptor

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Adjusting timing of doses, hydration, or meal composition can often resolve mild side effects without stopping either therapy