Research indicates that ceasing GLP-1 medications 3 to 5 days prior to surgery still posed a risk for delayed wake-up, whereas a 14-day hiatus before significant operations such as total joint replacements is ideal to reduce the chance of retained stomach contents and anesthesia issues
It's going to make a difference in how our whole body functions on a cellular level, she says
Unlike FDA-approved injectable tirzepatide (sold under brand names like Mounjaro and Zepbound ), oral drop versions have not been proven safe or effective in large human clinical trials
Therefore, based on the current findings showing a downregulation in NTS PPG expression by HFSD diet induced obesity, it is tempting to speculate that this effect might exacerbate or perpetuate a chronic hyperphagic effect that sustains obesity
However, existing studies suggest that, despite these variations, the overall safety profiles of tirzepatide and semaglutide for South Asians are generally consistent with those observed in other populations [12,13]
