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Betaine supplementation is also common to promote the folate- and vitamin B12-independent conversion of homocysteine to methionine in the liver and kidney

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Published safety data shows negative results in repeated-dose toxicity studies, skin irritation protocols, sensitization assays, and genotoxicity testing

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In case fertilization by spermatozoa does not occur, spontaneous free radical production leads to overcapacitation and ultimately induces oxidative stress