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In these first short-term clinical trials, focused on safety and dose optimisation, the administration of two different GLP-1R/GcgR co-agonists reduced HbA 1c in overweight diabetic individuals, with some degree of body weight loss [69]

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Experimental research also suggests that GLP-1 signaling may impact energy expenditure, metabolic flexibility, and glucose transport mechanisms

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This project will provide crucial insights into how GLP-1-based medications influence opioid reward and craving and will guide clinical collaborators in designing optimal dosing strategies for future human trials