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Chemical Engineering Journal, 481 , 149757.
Similar to lactose intolerance, this leads to osmotic effects in the small intestine and fermentation of undigested sugars in the large intestine, resulting in GI symptoms such as diarrhea, abdominal pain, bloating, and gas.18 SID is diagnosed either through disaccharidase assays that assess the sucraseisomaltase activity of biopsies obtained from the small intestine or through breath testing.18,19 While SID previously was thought to be a rare condition, a recent systematic review found that sucrase and maltase deficiency was present in approximately 9% of pediatric patients undergoing esophagogastroduodenoscopy, as assessed by disaccharidase assays.20 There are three types of SID: congenital SID, a homozygous recessive disorder
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