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A study of 25 obese patients with T2DM showed that patients treated with metformin and sulfonylurea/DPP-4 inhibitors for 6 months who took GLP-1RA (exenatide19, six cases) had significantly reduced average body weight, glycosylated hemoglobin, and intrahepatic lipids 293

FDA approval for both covers adults with obesity or those who are overweight with at least one weight-related health condition

Psychiatry 79 , 516525 (2016)

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We also demonstrate that mitochondrial metabolism may have a role in modulating both intrinsic and acquired 5FU resistance