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In a phase 2 trial, people with T2D and overweight/obesity achieved greater mean WL with cagrisema 2.4 mg compared to cagrilintide 2.4 mg or semaglutide 2.4 mg alone after 32 weeks of treatment (15.6% WL vs

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This has led to the hypothesis that adding glucagon receptor agonism could counterbalance potential lipid-storing effects by enhancing energy expenditure and promoting lipid mobilization [13]