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SCFAs mitigate allergic airway inflammation via GPR41/43-mediated suppression of Th2 responses and HDAC inhibition-induced Treg cell expansion, as evidenced by their therapeutic efficacy in murine asthma models (Zhang et al., 2025)

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Importantly, this relationship is relevant to humans as individuals with exceptional longevity are enriched with functional IGF-1R mutations 13 , while low IGF-1 levels predict better survival in female nonagenarians 16

10.3390/ijms21207608 [DOI] [PMC free article] [PubMed] [Google Scholar] 3.Barygina VV, Becatti M, Soldi G, Prignano F, Lotti T, Nassi P, et al