While natural options like botanical extracts, probiotics, and prebiotics may not be as powerful as pharmaceutical GLP-1s, emerging research shows these natural alternatives can deliver some of the benefits without the cost or side effects of prescription medications
The volume of scientific publications and intellectual property submissions echo this
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Moreover, in subjects with diabetes who were at high risk of cardiovascular events, treatment with GLP-1R agonists based on the structure of endogenous GLP-1, namely liraglutide, semaglutide, albiglutide, and dulaglutide, has demonstrated reductions in major adverse cardiovascular events (MACEs) that appear to be unrelated to the glycemic effects of these agents (1316)
By stimulating glucose-dependent insulin secretion and suppressing glucagon production, they are a cornerstone of the treatment of type 2 diabetes (DM2), particularly in patients with a higher risk of cardiovascular disease ( This narrative review describes the complex interplay between GLP-1 signalling and intestinal inflammation, highlighting both the potential benefits and limitations of GLP1 RAs in IBD management, with a particular focus on their promising role in selected obese IBD patients