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In patients with cancer, BTLA is highly expressed on tumor-specific T cells, and its positive expression in various tumor-infiltrating lymphocytes (TILs) is associated with poor prognosis ( The BTLA ligand, herpesvirus entry mediator (HVEM), induces tyrosine phosphorylation and mediates the recruitment of Src homology 2 (SH2) domain-containing phosphatases 1/2
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