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Given that GLP-1 receptor agonists require sustained exposure for cardiovascular and renal benefits (2, 3), understanding treatment initiation effects may have limited clinical use in this complex post-transplant milieu, in which multiple factors influence outcomes

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When 503A or 503B compounding pharmacies prepare tirzepatide formulations for patients, they frequently add cyanocobalamin or methylcobalamin to the vial

However, over the next year, initiation slowed and even reversed: with first-time prescribing rates declining 31% by June 2025, reflecting an average month-over-month decrease of 0.004 percentage points