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Human glutathione transferase A44: An alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation
The disrupted microbiome interacts with host immunity through mechanisms such as impaired TLR signaling, persistent inflammasome activation, and excessive protease release, all of which degrade extracellular matrix and hinder re-epithelialization
The trial enrolled 338 adults with a body mass index of 30 kg/m or greater, or 27 kg/m or greater with at least one weight-related condition, excluding individuals with type 2 diabetes
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