Both increase cortisol and impair insulin sensitivity, which blunts the effects of tirzepatide [the active ingredient in Zepbound]. Studies have shown that stress contributes to weight gain through several factors: It messes with your brain and ability to self-regulate, so its tougher to stick to your diet and weight loss goals It increases the production of appetite hormones , so you feel hungrier It makes you more likely to overeat, especially foods that are high in fat, sugar, and overall calories Emotional eating , binge-restriction cycles, and resistance to meal structure can persist even with reduced hunger on Zepbound, Dr
Thus, Western diet shifts the GH/IGF-1 axis to abnormally high levels, just in the opposite direction of low IIS observed in Laron syndrome [1, 2] (Figure 1)
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