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From a clinical point of view, T2DM patients are often accompanied by obesity, atherosclerotic disease, dyslipidemia, and hypertension (3, 4), in which more than 50% of T2DM patients have been reported to be obese (3, 5)

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Also high-valent chromium(VI) is able to generate reactive ROS during its conversion to the stable Cr 3+ oxidation state [13] and this mechanism has been associated to the recognized carcinogenic activity of chromate salts [14]

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