rebound weight gain after stopping semaglutide or tirzepatide is real, but it’s not because the body is “damaged”—it reflects how the body adapts after weight loss. When the medication is stopped, Weight Comes Back When You

Symptoms are typically most pronounced during dose escalation and often diminish over time as tolerance develops

Acetaminophen: Old drug, new issues

The real mechanism (lowering the stress hormone cortisol that impairs the prefrontal cortex and hippocampus, plus a GABA-mimetic and mild acetylcholinesterase action)

Chem Biol Interact 298:5765 Song M, Xia B, Li J (2006) Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1beta, and nuclear factor kappaB in trinitrobenzene sulphonic acid induced colitis in rats

Your stomach will eventually adjust to eating less