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However, metformin is oral, inexpensive, and has an extensive safety record, making it the preferred initial therapy

1B,C, and in ( C ) NMNAT1 and ( D ) NMNAT3 transgenic or wild-type (WT) littermates treated with Dox, as in main Fig

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Abstract Purpose of Review Abdominal pain in constipation-predominant irritable bowel syndrome (IBS-C) and functional constipation (FC) remains a difficult clinical challenge due to unclear pathophysiological mechanisms and limited pain-targeted treatments

doi: 10.1016/j.redox.2020.101799 218 ZhengDLiuJPiaoHZhuZWeiRLiuK