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The mechanism of action involves mimicking the naturally occurring GLP-1 hormone, which plays multiple roles in metabolic regulation

Maximum Efficacy Needs: While the new oral formulations are high-dose and designed to rival the injection, some clinical data suggest the injectable version (at the 2.4mg dose) offers slightly more consistent weight loss outcomes across large populations, simply because it removes the variable of absorption

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Key players today include Mounjaro (tirzepatide) a dual-agonist of GLP-1 and GIP receptors and coming soon, Retatrutide a triple-receptor agonist (GLP-1, GIP and glucagon) that has shown even stronger early results