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The recommended dosage in patients with hepatic impairment is the same as those with normal hepatic function

It is indicated for the treatment of adult patients with the following conditions: Metastatic colorectal cancer who have received prior treatment with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if they have RAS wild-type, an anti-EGFR therapy

The term "amplification" as used herein refers to the production of additional copies of a nucleic acid sequence and is generally carried out using polymerase chain reaction (PCR) technologies well known in the art (Dieffenbach, C.W

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